Terroirs, Plants, Animal and Humans: Phyto-melatonin and Evolution of Life
Date: Saturday, March 27 @ 15:14:40 EDT
Today probably majority of adults after the age of 50 in developed countries are deficient in melatonin and they may have a newly recognized disease-the chronic melatonin deficiency syndrome (CMDS). Half of population has an insomnia which compromises the synthesis, and low levels of the endogenous melatonin hormone from pineal gland accompanied by chronic reduced intake of phyto-melatonin from nature plays a vital role. In 1995 discovered in flowers and plants the natural analog of the human indole-amine has changed completely the view on science of nutrition!
The study will begin at GMUís Arch Lab, as a part of an independent post-doc nutritional neuroscience and computational gerontology project by Dr. Victor Ananyev guided by the Department of Psychology and the Neuro-imaging Core of Krasnow Institute and will evolve into a multi-center, multi-country scientific endeavor focused on evolutionary dual connections of melatonin as a human hormone and as a micronutrient which acc u mulated in soil, effectively absorbed and synthesized by plants, consumed by mammals, swiftly crosses the humanís blood-brain barrier and plays enormous role in health and longevity of all living species.
The article will be published in Gerontologist and/or American Journal of Clinical Nutrition. The new study hypothesizes that the synthetic melatonin(N-acetyl-5-methoxytryptamine), which is identical to endogenous melatonin and phyto-melatonin from plants, works on both young and aging animals and humans to increase the anti-inflammatory, anti-oxidant and anti-aging properties also preventing memory and cognitive decline. The research will be carried out over a two-year period including the animal studies and clinical observations and will have a significant impact on paradigm shift in nutritional science on endogenous production of melatonin, increased intake of phyto-melatonin from plants-based diet and its role in human mental and physical health.
The 90 days animal study will use four groups of rats: first group of the rats who eat normal diets containing miniscule amounts of melatonin from a natural low concentrations of melatonin sources during the artificial light. The second group who eats the melatonin enriched plants diet only under 12 hours of every day sunlight. The third group will be given a melatonin supplement of 0.025 mg per kg plus melatonin enriched diet under the natural sunlight, while the control group will have only its regular diet with no exposure to the sun or artificial light. The hypothesis will be confirmed with behavioral tests in cognitive functioning with highest improvement in the rats of the third group with increased synapto-genesis, neuro-genesis, axonal and dendritic arborization in the brain during autopsies.
"We will be really pleased with the positive outcome and public health implications of our studies," says the University professor and cognitive neuroscientist Raja Parasuraman. We will have the collaborative research on phyto-melatonin with the Department of Cellular and Structural Biology at the University of Texas in San Antonio. "We also in a process of developing a promising strategy and mathematical model for the emerging new discipline of nutritional neuroscience of aging and take the first step in locating the funding source for multi-center, multi-country clinical trials. The study on melatonin in human cognitive aging will be continued in Dr. Ananyevís native country of Ukraine.
Melatonin, Plasticity and Aging
"It seems plausible to use melatonin for memory, emotion, learning, attention and behavior modulation because melatonin is a natural radical scavenger and potent anti-oxidant, a molecule critical for healthy and successful aging. Melatonin enhances the axonal connectivity and action potentials on neuronal level. As a result, it enhances the brains plasticity, stimulate synaptic and neuro-genesis says Dr. Ananyev.
Melatonin in diet:
Melatonin is an essential functional micronutrient for plants and humans. Melatonin serves several important functions:
● High concentrations in seeds- to reduce the oxidative damage in next generation of plants and prevent diseases in humans
● High levels at sunset Ėmodulation of anti-oxidative enzymes in plants and high levels of endogenous melatonin in humans at night
● Reduce in plants and humans the oxidative stress from environmental contaminants and pollutants
Regulation of protective enzymes production and control of cell senescence
● Coordination of plant and human photoperiodic and reproductive physiology
● Regulation of wake/sleep cycle, jet leg and insomnia symptoms reduction and during night shift work
● Anti-aging and immune enhancing capabilities
● Enhancement in cancer therapy and during post-operative period
● Hypothermic and sleep inducing effect plays a role in longevity
● Rejuvenation of degenerative thymus in aging animals and probably in humans
● Overall improvement of quality of life and well being
"In our study we are confident in exploring the elusive plant signaling behavior and chrono-biology, the plants intimate relationship with animal kingdom and humans, therefore we convince the public that future of healthcare lies in careful assessing of patientís nutritional and neuro-endocrine status, balancing the hormones levels such as melatonin, vitamin D and cortisol which are vitally important for long, healthy and happy life ," he says.
Before the results of the study become available to the public, Dr. Ananyev recommends to increase their melatonin intake by eating more walnuts, almonds, pumpkin and sunflower seeds, fruits and berries such as tart cherries, drink 1 glass of beer with lots of hops ( extract of hops has a strong affinity for serotonin and melatonin receptors) and/or 1 glass of red wine( more melatonin in red wine than in white) at night. If sleep studies and measurement of melatonin levels detect the chronic melatonin deficiency the researcher recommends the supplementation with melatonin 0.025-0.035 mg per kg of body weight or 3-6 mg before going to bed.
Study will find that melatonin in nature as a core ingredient in new diet improves health and slow down aging